(R)-4-hydroxyphenyllactate dehydrogenase

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(R)-4-hydroxyphenyllactate dehydrogenase
EC number
CAS number 101754-02-3
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a (R)-4-hydroxyphenyllactate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+

The 3 substrates of this enzyme are (R)-3-(4-hydroxyphenyl)lactate, NAD+, and NADP+, whereas its 4 products are 3-(4-hydroxyphenyl)pyruvate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase. Other names in common use include (R)-aromatic lactate dehydrogenase, and D-hydrogenase, D-aryllactate. This enzyme participates in tyrosine and phenylalanine catabolism.


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